CPCP Retreat 2016: Neuroimage-Based Phenotyping and the Problem of AD
Symposium Video
Alzheimer's Disease is clinically characterized by the appearance of plaques and tangles in the brain, the phenotypic manifestation in patients is dementia. In order to prevent Alzheimer's disease it is necessary to develop a predictive computational framework that can differentiate the effects of normal aging on the brain from the preclinical Alzheimer's disease. Dr. Sterling Johnson describes the work of the Neuroimage-based Phenotyping Project at the CPCP toward this predictive goal. The results of this work will be applied to identify people who are candidates for early intervention trials addressing prevention of Alzheimer's Disease during the earliest stages of the disease. These early stages often occur more then 20 years before the onset of dementia.