Aug 15, 2017

High-throughput computing and machine learning boost drug screening

High throughput screening is a powerful, albeit expensive, method of drug discovery. The process can be made more cost effective by first using docking programs to do virtual screening of candidate drugs.  In recent research, a CPCP team has shown that virtual screening can be made significantly more effective by coupling high-throughput computing, machine-learning, and mixture modeling methods to integrate the results of multiple docking programs.  Read a UWMadScience story about the work here:

Jun 2, 2017

CPCP sponsors Big Data Analytics-as-a-Service workshop

The first workshop on Big data analytics-as-a-Service: Architecture, Algorithms, and Applications in Health Informatics is taking place on August 14, 2017 (in conjunction with KDD 2017) in Halifax, Nova Scotia, Canada. The workshop will consist of a combination of invited keynote speakers, panel discussion, and paper/poster presentations.

Oct 27, 2016

CPCP at the Wisconsin Science Festival

CPCP faculty, postdocs, staff, and graduate students worked together to develop and present three interactive Big Data exploration stations at the 2016 Wisconsin Science Festival. The Wisconsin Science Festival is a statewide event that strives to inspire curiosity and creativity by providing opportunities for people of all ages to explore, engage and discover science. This year the Wisconsin Science Festival event at the University of Wisconsin-Madison was attended by a large number of community members in the Madison area including more than 4,000 children on school field trips.

This outreach provided an opportunity for visitors to discover several types of Big Data studied in CPCP and to interact with some of the scientists working in the center. Visitors also had the opportunity to learn about the challenges faced by CPCP researchers as they work to develop new methods of analyzing biomedical Big Data with the goal of improving human health. At our neuro-imaging exploration station, visitors explored MRI images of the brain that CPCP researchers are using to predict Alzheimer’s disease. Our EHR exploration station used a set of Pokémon-based games to demonstrate to visitors the challenges facing researchers as they study electronic health records. At our final exploration station, visitors participated in a crowdsourced assembly of a human gene sequence using colored beads to represent the bases in DNA sequences. This activity provided an opportunity to discuss the Big Data challenges faced by researchers in CPCP’s Epigenome- and Transcriptome-based Phenotyping projects. 

Aug 18, 2016

UW2020 WARF Discovery Initiative Grant Awarded

The CPCP Phenotype Models for Breast Cancer Screening project team was recently awarded a 2-year, $500,000 grant to advance the precise targeting of breast cancer prevention and early detection by rapidly moving from the discovery of individual DNA variants called single nucleotide polymorphisms (SNPs) that appear to predict the risk of developing breast cancer, to their application in clinical settings. The group will also add to the predictive power of SNPs by pairing them with information on an observed physical difference --breast density -- that captures the effects of both genes and the environment.

This UW2020 WARF Discovery Initiative grant is funded jointly by the Office of the Vice Chancellor for Research and Graduate Education and the UW Carbone Cancer Center.

Jul 26, 2016

Dr. Bourne Keynote Address to CPCP Retreat 2016

Mar 1, 2016

New BD2K training grant in Bio-Data Science

Problems in the generation, acquisition, management, analysis, visualization, and interpretation, of data, which have always been important players in biomedical science, now assume leading roles in the massive effort to understand health and disease. The unprecedented size, complexity, and heterogeneity of big biomedical data demands research that will allow us to more efficiently extract knowledge from data in order to make better predictions, to characterize biological systems, and generally to enable subsequent investigation. Modern biological, medical, and health studies often involve data sets from which useful, accurate information cannot be efficiently extracted with available methods. 

Research to improve the analysis of big biomedical data is active at the interface of computer sciences, statistics, and various biomedical disciplines, including genomics, molecular biology, neuroscience, cancer research, and population health.  The mission of the Bio-Data Science (BDS) training program is to provide predoctoral research training at this interface, preparing graduate students for key roles in academia, industry, or government. The BDS training program is supported by a T32 grant from the National Library of Medicine, and will be tightly integrated with the activities of the Center for Predictive Computational Phenotyping.

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